Vitamin C; Ascorbic Acid (Vitamin C)
(in 18,935 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend


1. Anti-aging - Prevents or slows aging, and causes the skin to appear more youthful
2. Antioxidant - Reduces oxidation to prevent the formation of free radicals which may be harmful to health.
3. Dietary / Nutritional Supplement - Vitamins, minerals, proteins, fatty acids or probiotics that improves nutritional intake
4. Drug / Medicine - Treats, alleviate, cure, or prevents sickness. As officially declared by a governmental drug/medicine regulatory body
5. Experimental / Patented - Relatively new ingredient with limited data available
6. Fungicide / Herbicide - Kills or inhibits unwanted vegetation
7. Preservative - Prevents and inhibits the growth of unwanted microorganisms which may be harmful
8. Skin Whitening Agent - Reduces the melanin content of the skin
Ascorbic acid is a six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant with the E number 300. Found in citrus and other fruits, and in vegetables, vitamin C cannot be produced or stored by humans and must be obtained in the diet.
It is approved to use as food additive in EU and generally recognized as safe food substance in US.
Scientific References:
Regulatory References:
1. US FDA Food Additives Status List [2018]
- Ascorbic acid
2. EU Approved Food Additive [2018]
- E300
3. Cosmetic Ingredient Review
- L-Ascorbic Acid
4. Japan’s List of Designated Food Additives under Article 10 of the Food Sanitation Act
- L-Ascorbic Acid (Vitamin C)
5. WHO Model List of Essential Medicines [2019]
- ascorbic acid
6. US FDA Generally Recognized As Safe (GRAS) (21 CFR 182) [2017]
- § 182.3013 - Ascorbic acid, § 182.8013 - Ascorbic acid

Safety and Hazards (UN GHS):

1. Causes skin irritation (H315)
2. Causes serious eye irritation (H319)

Potential Health Concerns For:

1. Acute Kidney Injury (PubMed ID:18714631)
2. Anemia (PubMed ID:17497326)
3. Bone Diseases (PubMed ID:21281732)
4. Carcinoma, Hepatocellular (PubMed ID:19229483)
5. Cardiovascular Diseases (PubMed ID:15531665)
6. Catalepsy (PubMed ID:3703914)
7. Dehydration (PubMed ID:17497326)
8. Diabetes Mellitus, Type 2 (PubMed ID:16506275)
9. Drug Overdose (PubMed ID:18714631)
10. Eales disease (PubMed ID:9068938)
11. Fatigue (PubMed ID:17497326)
12. Hallucinations (PubMed ID:8767052)
13. Hyperoxaluria (PubMed ID:18042297)
14. Hyperplasia (PubMed ID:6681793)
15. Hypertension (PubMed ID:15190049)
16. Inflammation (PubMed ID:23692848)
17. Kidney Tubular Necrosis, Acute (PubMed ID:1678558)
18. Learning Disorders (PubMed ID:19703495)
19. Liver Neoplasms, Experimental (PubMed ID:18544905)
20. Micronuclei, Chromosome-Defective (PubMed ID:17169990)
21. Nausea (PubMed ID:17497326)
22. Necrosis (PubMed ID:19482829)
23. Nephritis, Interstitial (PubMed ID:18042297)
24. Nephrolithiasis (PubMed ID:18042297)
25. Papilloma (PubMed ID:1752781)
26. Precancerous Conditions (PubMed ID:1752781)
27. Psychoses, Substance-Induced (PubMed ID:8767052)
28. Renal Insufficiency (PubMed ID:18042297)
29. Stomach Neoplasms (PubMed ID:6680729)
30. Thrombocytopenia (PubMed ID:17497326)
31. Thrombosis (PubMed ID:26139164)
32. Urinary Bladder Neoplasms (PubMed ID:1752781)

Potential Health Benefits For:

1. Acute Lung Injury (PubMed ID:15612528)
2. Amnesia (PubMed ID:7582819)
3. Anemia, Iron-Deficiency (PubMed ID:22169218)
4. Anemia, Megaloblastic (PubMed ID:16353713)
5. Anemia, Sideroblastic (PubMed ID:673833)
6. Anxiety Disorders (PubMed ID:29572072)
7. Arsenic Poisoning (PubMed ID:20028703)
8. Ascorbic Acid Deficiency (PubMed ID:19710200)
9. Bacterial Infections (PubMed ID:12669766)
10. Blindness (PubMed ID:1341094)
11. Brain Diseases (PubMed ID:20305954)
12. Brain Injuries (PubMed ID:31739238)
13. Brain Ischemia (PubMed ID:18044087)
14. Breast Neoplasms (PubMed ID:16443354)
15. Carcinogenesis (PubMed ID:32805337)
16. Carcinoma (PubMed ID:16345077)
17. Cardiomyopathies (PubMed ID:10533957)
18. Cardiotoxicity (PubMed ID:23194016)
19. Cardiovascular Abnormalities (PubMed ID:20068362)
20. Cataract (PubMed ID:8698541)
21. Cell Transformation, Neoplastic (PubMed ID:21344382)
22. Charcot-Marie-Tooth Disease (PubMed ID:15034573)
23. Chemical and Drug Induced Liver Injury (PubMed ID:21791388)
24. Chromosome Aberrations (PubMed ID:7678149)
25. Chromosome Breakage (PubMed ID:30597948)
26. Common Cold (PubMed ID:17323712)
27. Complex Regional Pain Syndromes (PubMed ID:20224742)
28. Coronary Disease (PubMed ID:8698541)
29. Death (PubMed ID:30606963)
30. Depressive Disorder (PubMed ID:33872575)
31. Diabetic Nephropathies (PubMed ID:18763636)
32. Diabetic Retinopathy (PubMed ID:18779489)
33. Disease Progression (PubMed ID:23859036)
34. Drug-Related Side Effects and Adverse Reactions (PubMed ID:19391111)
35. Dysbiosis (PubMed ID:33475796)
36. Endotoxemia (PubMed ID:24239723)
37. Erythema (PubMed ID:19800932)
38. Glioma (PubMed ID:23859036)
39. Glycosuria (PubMed ID:7909430)
40. Growth Disorders (PubMed ID:20068362)
41. HIV Infections (PubMed ID:9764785)
42. Heart Defects, Congenital (PubMed ID:16080930)
43. Hernia, Diaphragmatic (PubMed ID:16490937)
44. Hyperalgesia (PubMed ID:30552955)
45. Hyperinsulinism (PubMed ID:31005848)
46. Hypertension, Renal (PubMed ID:20053703)
47. Hypotension (PubMed ID:15612528)
48. Hypothyroidism (PubMed ID:12587721)
49. Immunologic Deficiency Syndromes (PubMed ID:27020608)
50. Infertility, Male (PubMed ID:30140404)
51. Insulin Resistance (PubMed ID:31005848)
52. Intestinal Diseases (PubMed ID:33475796)
53. Kidney Diseases (PubMed ID:17448119)
54. Lead Poisoning, Nervous System, Childhood (PubMed ID:22056337)
55. Leukemia, Lymphoid (PubMed ID:12750841)
56. Liver Cirrhosis (PubMed ID:22149461)
57. Lung Diseases (PubMed ID:16863852)
58. Lung Neoplasms (PubMed ID:16401635)
59. Manganese Poisoning (PubMed ID:21940818)
60. Mercury Poisoning (PubMed ID:18536492)
61. Muscle Cramp (PubMed ID:11427639)
62. Muscular Diseases (PubMed ID:5111643)
63. Myocardial Infarction (PubMed ID:16444596)
64. Neoplasms (PubMed ID:20433922)
65. Neoplasms, Experimental (PubMed ID:19197388)
66. Nerve Degeneration (PubMed ID:17959157)
67. Nervous System Diseases (PubMed ID:2554183)
68. Neurodegenerative Diseases (PubMed ID:22056337)
69. Obesity (PubMed ID:17217161)
70. Oligospermia (PubMed ID:19429265)
71. Pain, Postoperative (PubMed ID:5111643)
72. Pancreatic Neoplasms (PubMed ID:24126434)
73. Pathological Conditions, Anatomical (PubMed ID:30140404)
74. Peripheral Nervous System Diseases (PubMed ID:30552955)
75. Peripheral Vascular Diseases (PubMed ID:20174656)
76. Poisoning (PubMed ID:22245848)
77. Polycystic Ovary Syndrome (PubMed ID:26545973)
78. Prenatal Exposure Delayed Effects (PubMed ID:27020608)
79. Prostatic Neoplasms (PubMed ID:16345077)
80. Proteinuria (PubMed ID:20360751)
81. Pseudoxanthoma Elasticum (PubMed ID:17845175)
82. Puberty, Delayed (PubMed ID:28729172)
83. Pulmonary Edema (PubMed ID:15612528)
84. Pulmonary Eosinophilia (PubMed ID:14606601)
85. Pulmonary Fibrosis (PubMed ID:18759078)
86. Retinitis Pigmentosa (PubMed ID:16849425)
87. Scurvy (PubMed ID:24162740)
88. Seizures (PubMed ID:17543232)
89. Skin Diseases (PubMed ID:18709164)
90. Status Epilepticus (PubMed ID:17512118)
91. Stomach Ulcer (PubMed ID:17218764)
92. Stroke (PubMed ID:16403987)
93. Substance Withdrawal Syndrome (PubMed ID:19418264)
94. Testicular Diseases (PubMed ID:25637669)
95. Weight Loss (PubMed ID:30140404)

User Comments:

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