Turmeric; Curcumin
(in 3,212 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend


1. Colorant - Pigments or dyes that are added in order to change or enhance the color.
2. Flavor / Flavoring / Flavor Enhancer - Provides or enhances a particular taste or smell.
3. Fragrance / Fragrance Component - Provides or enhances a particular smell or odor.
Curcumin is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae.
The most common applications are as an ingredient in dietary supplement, in cosmetics, and as flavoring for foods, such as turmeric-flavored beverages in the Indian Subcontinent and Southeast Asia. As a food additive (E number 100) for gold-orange coloring in turmeric and prepared foods. It is approved for use as food coloring in EU and US.
Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive- oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer.
Scientific References:
Regulatory References:
- Ref: IV/114
2. US FDA Color Additives Status List [2015]
- §73.600, §73.615
3. EU Approved Food Additive [2018]
- E100
4. International Fragrance Association Transparency List [2015]
- Turmeric

Safety and Hazards (UN GHS):

1. May be fatal if swallowed and enters airways (H304)
2. Causes skin irritation (H315)
3. May cause an allergic skin reaction (H317)
4. Causes serious eye irritation (H319)
5. May cause respiratory irritation (H335)
6. Harmful to aquatic life with long lasting effects (H412)

Potential Health Concerns For:

1. Chromosome Aberrations (PubMed ID:2209081)
2. Eye Diseases (PubMed ID:19778247)
3. Lung Neoplasms (PubMed ID:19359593)
4. Splenomegaly (PubMed ID:24634837)

Potential Health Benefits For:

1. Acute Kidney Injury (PubMed ID:17076682)
2. Acute Lung Injury (PubMed ID:25461551)
3. Adenoma (PubMed ID:12778080)
4. Adenomatous Polyposis Coli (PubMed ID:22830632)
5. Airway Obstruction (PubMed ID:28951138)
6. Albuminuria (PubMed ID:10694226)
7. Alcohol-Related Disorders (PubMed ID:17887948)
8. Alzheimer Disease (PubMed ID:15590663)
9. Amnesia (PubMed ID:18930076)
10. Arsenic Poisoning (PubMed ID:21332098)
11. Arthritis, Experimental (PubMed ID:16562833)
12. Arthritis, Rheumatoid (PubMed ID:16807698)
13. Ascites (PubMed ID:25130536)
14. Asthenozoospermia (PubMed ID:20182699)
15. Atherosclerosis (PubMed ID:18704882)
16. Autoimmune Diseases (PubMed ID:19761891)
17. Brain Edema (PubMed ID:29571711)
18. Brain Injuries, Traumatic (PubMed ID:29571711)
19. Brain Ischemia (PubMed ID:16770732)
20. Brain Neoplasms (PubMed ID:17596214)
21. Breast Neoplasms (PubMed ID:16243823)
22. Capillary Leak Syndrome (PubMed ID:18635243)
23. Carcinoma (PubMed ID:18593918)
24. Carcinoma, Ductal, Breast (PubMed ID:19944674)
25. Carcinoma, Ehrlich Tumor (PubMed ID:31628941)
26. Carcinoma, Hepatocellular (PubMed ID:22197969)
27. Carcinoma, Non-Small-Cell Lung (PubMed ID:18414057)
28. Carcinoma, Squamous Cell (PubMed ID:18462866)
29. Cardiomegaly (PubMed ID:26612707)
30. Cardiomyopathies (PubMed ID:21378372)
31. Cardiotoxicity (PubMed ID:29315967)
32. Chemical and Drug Induced Liver Injury (PubMed ID:1394115)
33. Cocaine-Related Disorders (PubMed ID:20383415)
34. Cognition Disorders (PubMed ID:19765566)
35. Colitis (PubMed ID:15604057)
36. Coloboma (PubMed ID:18809619)
37. Colonic Neoplasms (PubMed ID:16340194)
38. Corneal Neovascularization (PubMed ID:18497527)
39. Cystitis (PubMed ID:19413659)
40. Death (PubMed ID:24231732)
41. Dementia (PubMed ID:20369229)
42. Diabetes Mellitus, Type 2 (PubMed ID:18403477)
43. Diabetic Cardiomyopathies (PubMed ID:28700904)
44. Diabetic Nephropathies (PubMed ID:17002671)
45. Diarrhea (PubMed ID:27194111)
46. Drug-Related Side Effects and Adverse Reactions (PubMed ID:28733234)
47. Duodenal Ulcer (PubMed ID:17351913)
48. Edema (PubMed ID:19413659)
49. Emphysema (PubMed ID:28951138)
50. Enteritis (PubMed ID:20885979)
51. Fatty Liver (PubMed ID:19297423)
52. Fibrosis (PubMed ID:18705752)
53. Gastrointestinal Hemorrhage (PubMed ID:28733234)
54. Gastrointestinal Neoplasms (PubMed ID:18462866)
55. Glioblastoma (PubMed ID:17596214)
56. Head and Neck Neoplasms (PubMed ID:18462866)
57. Heart Diseases (PubMed ID:9647462)
58. Helicobacter Infections (PubMed ID:21283694)
59. Hemolysis (PubMed ID:17665866)
60. Hemorrhage (PubMed ID:19413659)
61. Hepatic Veno-Occlusive Disease (PubMed ID:23845850)
62. Hepatomegaly (PubMed ID:27208389)
63. Hereditary Sensory and Motor Neuropathy (PubMed ID:17701891)
64. Hyperalgesia (PubMed ID:16584726)
65. Hypercholesterolemia (PubMed ID:18704882)
66. Hyperglycemia (PubMed ID:25541178)
67. Hyperlipidemias (PubMed ID:10694226)
68. Hypertension (PubMed ID:24662163)
69. Hyperthyroidism (PubMed ID:19914224)
70. Hypertrophy (PubMed ID:29421648)
71. Hypoalbuminemia (PubMed ID:10694226)
72. Hypothyroidism (PubMed ID:19174171)
73. Inflammation (PubMed ID:16956363)
74. Inflammatory Bowel Diseases (PubMed ID:18200517)
75. Insulin Resistance (PubMed ID:25268984)
76. Intestinal Neoplasms (PubMed ID:10783313)
77. Kidney Diseases (PubMed ID:19345714)
78. Kidney Failure, Chronic (PubMed ID:19225048)
79. Learning Disorders (PubMed ID:21839772)
80. Leiomyoma (PubMed ID:18555241)
81. Leukemia (PubMed ID:18462866)
82. Liver Cirrhosis, Experimental (PubMed ID:17355460)
83. Liver Diseases (PubMed ID:16956363)
84. Lymphoma (PubMed ID:18462866)
85. Lymphoma, T-Cell (PubMed ID:16173963)
86. Melanoma (PubMed ID:17885582)
87. Memory Disorders (PubMed ID:17263510)
88. Mercury Poisoning (PubMed ID:20229497)
89. Mesothelioma (PubMed ID:21594647)
90. Mouth Neoplasms (PubMed ID:9589436)
91. Movement Disorders (PubMed ID:18022680)
92. Multiple Myeloma (PubMed ID:19372569)
93. Muscular Atrophy, Spinal (PubMed ID:17962980)
94. Muscular Diseases (PubMed ID:24863870)
95. Myelodysplastic Syndromes (PubMed ID:27430728)
96. Myocardial Infarction (PubMed ID:8534267)
97. Myocardial Ischemia (PubMed ID:20125031)
98. Myocarditis (PubMed ID:29315967)
99. Necrosis (PubMed ID:19002562)
100. Neoplasm Invasiveness (PubMed ID:18495463)
101. Neoplasms (PubMed ID:21397623)
102. Neoplasms, Experimental (PubMed ID:22258452)
103. Neoplasms, Hormone-Dependent (PubMed ID:12497104)
104. Neoplastic Processes (PubMed ID:26991801)
105. Nerve Degeneration (PubMed ID:23036615)
106. Nervous System Neoplasms (PubMed ID:18462866)
107. Neurobehavioral Manifestations (PubMed ID:25199698)
108. Neurotoxicity Syndromes (PubMed ID:21656326)
109. Obesity (PubMed ID:19297423)
110. Oligospermia (PubMed ID:20182699)
111. Osteoarthritis (PubMed ID:19889203)
112. Osteoporosis (PubMed ID:18719352)
113. Ovarian Neoplasms (PubMed ID:18462866)
114. Pancreatic Neoplasms (PubMed ID:17440100)
115. Parkinsonian Disorders (PubMed ID:25238331)
116. Poisoning (PubMed ID:27535828)
117. Polyuria (PubMed ID:29421648)
118. Prostatic Neoplasms (PubMed ID:10851300)
119. Proteinuria (PubMed ID:10694226)
120. Pulmonary Edema (PubMed ID:25461551)
121. Pulmonary Emphysema (PubMed ID:19168576)
122. Respiratory Distress Syndrome, Adult (PubMed ID:10666014)
123. Respiratory Insufficiency (PubMed ID:29480285)
124. Sarcoma (PubMed ID:18462866)
125. Seizures (PubMed ID:21211953)
126. Sepsis (PubMed ID:18389075)
127. Skin Neoplasms (PubMed ID:2435036)
128. Stomach Neoplasms (PubMed ID:1618892)
129. Stomach Ulcer (PubMed ID:16631530)
130. Ulcer (PubMed ID:19002562)
131. Urinary Bladder Neoplasms (PubMed ID:18593936)
132. Urogenital Neoplasms (PubMed ID:18462866)
133. Ventricular Dysfunction, Left (PubMed ID:26612707)
134. Weight Gain (PubMed ID:26713546)
135. Weight Loss (PubMed ID:19002562)

User Comments:

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