Retinol; Vitamin A
(in 6,820 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend

About:

Functions:
1. Anti-aging - Prevents or slows aging, and causes the skin to appear more youthful
2. Dietary / Nutritional Supplement - Vitamins, minerals, proteins, fatty acids or probiotics that improves nutritional intake
3. Exfoliant - Removes dead cells at the surface of the skin
4. Experimental / Patented - Relatively new ingredient with limited data available
5. Skin Whitening Agent - Reduces the melanin content of the skin
Vitamin A is effective for the treatment of Vitamin A deficiency. Vitamin A refers to a group of fat-soluble substances that are structurally related to and possess the biological activity of the parent substance of the group called all-trans-retinol or retinol. Vitamin A plays vital roles in vision, epithelial differentiation, growth, reproduction, pattern formation during embryogenesis, bone development, hematopoiesis, and brain development. It is also important for the maintenance of the proper functioning of the immune system. Retinol is the fat-soluble vitamin retinol. Vitamin A binds to and activates retinoid receptors (RARs), thereby inducing cell differentiation and apoptosis of some cancer cell types and inhibiting carcinogenesis. Vitamin A plays an essential role in many physiologic processes, including proper functioning of the retina, growth, and differentiation of target tissues, proper functioning of the reproductive organs, and modulation of immune function. [1]
Recent Findings:
Retinols/retinoids/retinals and all other derivatives of Vitamin A tend to have an adverse interaction with UV light (which may include radical formation, sensitization, or degradation). It is strongly advised to apply products containing Vitamin A and its derivatives in the absence of sunlight and to remove them prior to any sunlight exposure. This adverse interaction with UV light only pertains to contact-based products and not ingestion-based products. [2] [3] It should also not be applied to anywhere near the eyes due to the potential damage it may cause. [4]
Warning: Do not use in the presence of UV light (including sun exposure).
Scientific References:
2. Photodecomposition of Vitamin A and Photobiological Implications for the Skin. (Photochem. Photobiol., 83(2), 409–424. doi:10.1562/2006-10-23-ir-1065)
3. Photodecomposition and Phototoxicity of Natural Retinoids. (Int. J. Environ. Res. Public Health, 2(1), 147–155. doi:10.3390/ijerph2005010147)
4. Vitamin A activates rhodopsin and sensitizes it to ultraviolet light. (Vis. Neurosci., 28(06), 485–497. doi:10.1017/s0952523811000423)
5. In vitro and in vivo percutaneous absorption of retinol from cosmetic formulations: Significance of the skin reservoir and prediction of systemic absorption. (Toxicol. Appl. Pharmacol., 231(1), 117–121. doi:10.1016/j.taap.2008.04.006)
6. Characterization of Esterase and Alcohol Dehydrogenase Activity in Skin. Metabolism of Retinyl Palmitate to Retinol (Vitamin A) During Percutaneous Absorption. (Pharm. Res., 11(8), 1155–1159. doi:10.1023/a:1018941016563)
Regulatory References:
1. South Korea - Ministry of Food and Drug Safety - Prohibited/Restricted Chemicals
- Ref: 1222
2. CANADA INGREDIENT HOTLIST, List of Ingredients that are Restricted for Use in Cosmetic Products [2019]
- Retinol and its esters
3. Japan’s List of Designated Food Additives under Article 10 of the Food Sanitation Act
- Vitamin A (Retinol)
4. US FDA Generally Recognized As Safe (GRAS) Food Substances (21 CFR 184) [2017]
- § 184.1930 - Vitamin A

Safety and Hazards (UN GHS):

1. Harmful if swallowed (H302)
2. May cause an allergic skin reaction (H317)
3. Causes serious eye irritation (H319)
4. May damage fertility or the unborn child (H360)
5. May cause long lasting harmful effects to aquatic life (H413)

Potential Health Concerns For:

1. Abnormalities, Drug-Induced (PubMed ID:4810330)
2. Abnormalities, Multiple (PubMed ID:10992263)
3. Acute Kidney Injury (PubMed ID:1248399)
4. Adrenal Insufficiency (PubMed ID:665178)
5. Amblyopia (PubMed ID:7460169)
6. Anemia (PubMed ID:11965502)
7. Anemia, Hemolytic (PubMed ID:4684742)
8. Arnold-Chiari Malformation (PubMed ID:7229658)
9. Ascites (PubMed ID:4045180)
10. Asthma (PubMed ID:16732791)
11. Blindness (PubMed ID:12290005)
12. Bone Diseases (PubMed ID:946392)
13. Bone Diseases, Developmental (PubMed ID:7229658)
14. Brain Diseases (PubMed ID:4810330)
15. Brain Edema (PubMed ID:4593602)
16. Carcinoma, Hepatocellular (PubMed ID:11012474)
17. Chemical and Drug Induced Liver Injury (PubMed ID:16448456)
18. Cholestasis (PubMed ID:16175620)
19. Cholestasis, Intrahepatic (PubMed ID:17924304)
20. Cleft Palate (PubMed ID:16054864)
21. Craniofacial Abnormalities (PubMed ID:10992263)
22. Depressive Disorder (PubMed ID:4810330)
23. Diabetes Mellitus, Type 1 (PubMed ID:16506275)
24. Diplopia (PubMed ID:4473880)
25. Disease Models, Animal (PubMed ID:7229658)
26. Dizziness (PubMed ID:4473880)
27. Drug Eruptions (PubMed ID:11792017)
28. Drug Overdose (PubMed ID:4045180)
29. Dry Eye Syndromes (PubMed ID:16146918)
30. Eales disease (PubMed ID:9068938)
31. Ectromelia (PubMed ID:16054864)
32. Edema (PubMed ID:6071832)
33. Esophageal and Gastric Varices (PubMed ID:303561)
34. Eye Diseases (PubMed ID:15488795)
35. Fatigue (PubMed ID:6071832)
36. Fatty Liver (PubMed ID:6681608)
37. Fetal Death (PubMed ID:16028844)
38. Fetal Resorption (PubMed ID:16054864)
39. Fibromyalgia (PubMed ID:7610649)
40. Fibrosis (PubMed ID:10681193)
41. HIV Seropositivity (PubMed ID:17209195)
42. Headache (PubMed ID:4473880)
43. Heart Defects, Congenital (PubMed ID:10992263)
44. Hepatitis C, Chronic (PubMed ID:11012474)
45. Hepatomegaly (PubMed ID:6071832)
46. Hernia, Diaphragmatic (PubMed ID:17436238)
47. Hydrocephalus (PubMed ID:13410607)
48. Hypercalcemia (PubMed ID:11225264)
49. Hyperplasia (PubMed ID:10681193)
50. Hypertension, Portal (PubMed ID:10750659)
51. Hypertriglyceridemia (PubMed ID:4045180)
52. Hypervitaminosis A (PubMed ID:11824142)
53. Hypesthesia (PubMed ID:6701590)
54. Hypokinesia (PubMed ID:17673185)
55. Hypotrichosis (PubMed ID:6071832)
56. Idiopathic intracranial hypertension with papilledema (PubMed ID:7769163)
57. Inflammation (PubMed ID:6681608)
58. Intracranial Hypertension (PubMed ID:15955940)
59. Jaundice (PubMed ID:19944093)
60. Limb Deformities, Congenital (PubMed ID:16054864)
61. Liver Cirrhosis (PubMed ID:10750659)
62. Liver Cirrhosis, Experimental (PubMed ID:16248980)
63. Liver Diseases (PubMed ID:10424294)
64. Liver Diseases, Alcoholic (PubMed ID:16762690)
65. Liver Neoplasms (PubMed ID:2055368)
66. Lung Neoplasms (PubMed ID:27506545)
67. Malformations of Cortical Development (PubMed ID:8180004)
68. Microcephaly (PubMed ID:665178)
69. Multiple Myeloma (PubMed ID:16374440)
70. Muscular Diseases (PubMed ID:6071832)
71. Musculoskeletal Diseases (PubMed ID:4473880)
72. Nausea (PubMed ID:2403062)
73. Necrosis (PubMed ID:18676402)
74. Nephrosis (PubMed ID:12660332)
75. Neural Tube Defects (PubMed ID:16028844)
76. Neurobehavioral Manifestations (PubMed ID:6668507)
77. Neurotoxicity Syndromes (PubMed ID:12652617)
78. Pain (PubMed ID:4473880)
79. Pancytopenia (PubMed ID:6701590)
80. Papilledema (PubMed ID:151668)
81. Poisoning (PubMed ID:19145591)
82. Precancerous Conditions (PubMed ID:2055368)
83. Pregnancy Complications (PubMed ID:4810330)
84. Prenatal Exposure Delayed Effects (PubMed ID:665178)
85. Pseudotumor Cerebri (PubMed ID:11824142)
86. Reflex, Abnormal (PubMed ID:4473880)
87. Renal Insufficiency, Chronic (PubMed ID:8711172)
88. Schizophrenia (PubMed ID:4810330)
89. Spina Bifida Cystica (PubMed ID:8422324)
90. Spinal Dysraphism (PubMed ID:361928)
91. Teratozoospermia (PubMed ID:30944279)
92. Testicular Diseases (PubMed ID:30944279)
93. Urticaria (PubMed ID:11792017)
94. Vision Disorders (PubMed ID:4037599)
95. Vitamin A Deficiency (PubMed ID:16146918)
96. Vomiting (PubMed ID:2403062)
97. Weight Loss (PubMed ID:30944279)

Potential Health Benefits For:

1. Acne Vulgaris (PubMed ID:11824142)
2. Anemia, Iron-Deficiency (PubMed ID:16960172)
3. Bronchopulmonary Dysplasia (PubMed ID:15713907)
4. Cardiomyopathies (PubMed ID:8169849)
5. Cataract (PubMed ID:11438049)
6. Child Nutrition Disorders (PubMed ID:16153327)
7. Colonic Neoplasms (PubMed ID:16267017)
8. Corneal Diseases (PubMed ID:6716538)
9. HIV Infections (PubMed ID:16960176)
10. Ichthyosis (PubMed ID:2324882)
11. Infant, Newborn, Diseases (PubMed ID:6890166)
12. Intestinal Neoplasms (PubMed ID:4703115)
13. Liver Neoplasms, Experimental (PubMed ID:17113696)
14. Lung Diseases (PubMed ID:16863852)
15. Neoplasms (PubMed ID:6668507)
16. Neoplasms, Squamous Cell (PubMed ID:1277139)
17. Pigmentation Disorders (PubMed ID:19648781)
18. Psoriasis (PubMed ID:14746632)
19. Respiratory Distress Syndrome, Newborn (PubMed ID:16877224)
20. Skin Diseases (PubMed ID:18709164)

User Comments:

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