Phenylbenzimidazole Sulfonic Acid(in 820 products)
Potential Risk Index®:
About:
Functions:
1. Sunscreen - Physical sunscreens work by deflecting or scattering UV rays. Chemical sunscreens work by absorbing and dissipating the UV rays as heat.
Phenylbenzimidazole Sulfonic Acid is commonly used as a sunscreen agent.
Recent Findings:
Phenylbenzimidazole Sulfonic Acid (PBSA) degrades rapidly via radical photodegradation with the process being faster than biological degradation. [2] However, further additional analysis is needed on the photoproducts formed from the photodegradation of PBSA. [2]
In an in vitro study conducted, PBSA showed no "measurable binding affinity" for DNA and hence the probability of photosensitization is expected to be low. [3] It also "stressed that extensive animal and human studies have demonstrated the efficacy and safety of PBSA and other sunscreens in protecting skin from the injurious effects of solar UV radiation". [3]
A review found that PBSA is also commonly combined with octyl methoxycinnamate. [4] That "2-phenylbenzimidazole-5-sulfonic acid, were potential carcinogens based on these in vitro data" with " 2-phenyl-benzimidazole-5-sulfonic acid, prevented UVB-induced cyclobutane dimer formation in human skin". [4]
Scientific References:
1. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/33919
2. Photochemical degradation of sunscreen agent 2-phenylbenzimidazole-5-sulfonic acid in different water matrices. (Water Res., 47(15), 5865–5875. doi:10.1016/j.watres.2013.07.009)
3. Photosensitization of Guanine-Specific DNA Damage by 2-Phenylbenzimidazole and the Sunscreen Agent 2-Phenylbenzimidazole-5-sulfonic Acid. (Chem. Res. Toxicol., 12(1), 38–45. doi:10.1021/tx980158l)
4. A Review of Sunscreen Safety and Efficacy. (Photochem. Photobiol., 68(3), 243–256. doi:10.1111/j.1751-1097.1998.tb09677.x)
Regulatory References:
1. South Korea - Ministry of Food and Drug Safety - Prohibited/Restricted Chemicals
- Ref: 1127
2. EU CosIng Annex VI, LIST OF UV FILTERS ALLOWED IN COSMETIC PRODUCTS [2017]
- Ref: VI/6
3. Association of Southeast Asian Nations Annex VII, Allowed UV Filters
- 2-Phenylbenzimidazole-5-sulphonic acid and its potassium, sodium and triethanolamine salts
Safety and Hazards (UN GHS):
1. Causes skin irritation (H315)
2. Causes serious eye irritation (H319)
3. May cause respiratory irritation (H335)
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