Natamycin

(in 191 products)

1. Antimicrobial Preservative - Actively kills and inhibits the growth of unwanted microorganisms which may be harmful.

2. Drug / Medicine - Treats, alleviates, cures, or prevents sickness. As officially declared by a governmental drug/medicine regulatory body

3. Preservative - Prevents and inhibits the growth of unwanted microorganisms which may be harmful

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis . It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida , Aspergillus , Cephalosporium , Fusarium and Penicillium . Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid. Natamycin is a polyene amphoteric macrolide antibiotic with antifungal properties. Natamycin exerts its antifungal effects by binding to sterols in the fungal cell membrane thereby increasing membrane permeability. This leads to a leakage and loss of essential cellular constituents. Following ocular application, natamycin is retained in the conjunctival fornices and attains effective concentrations within the corneal stroma where it exerts its effect.

Natamycin is an antifungal medication used to treat fungal infections around the eye. This includes infections of the eyelids, conjunctiva, and cornea. It is used as eyedrops. Natamycin is also used in the food industry as a preservative with E number 235.

It is approved to use as food additive in EU and US.

1. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/5284447

1. US FDA Food Additives Status List [2018]

2. EU Approved Food Additive [2018]

- E235

3. Japan’s List of Designated Food Additives under Article 10 of the Food Sanitation Act

- Natamycin