Hydroxyacetophenone; 4-Hydroxyacetophenone
(in 6,461 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend


1. Antimicrobial Preservative - Actively kills and inhibits the growth of unwanted microorganisms which may be harmful.
2. Antioxidant - Reduces oxidation to prevent the formation of free radicals which may be harmful to health.
3. Drug / Medicine - Treats, alleviates, cures, or prevents sickness. As officially declared by a governmental drug/medicine regulatory body
4. Flavor / Flavoring / Flavor Enhancer - Provides or enhances a particular taste or smell.
4-Hydroxyacetophenone, also called Piceol, is a phenolic compound found in the needles and in mycorrhizal roots of Norway spruces (Picea abies). It is slightly soluble (in water) and a very weakly acidic compound.
Hydroxyacetophenone is a synthetic antioxidant and skin-conditioning ingredient. It also has the soothing ability due to its function to inhibit an enzyme (known as COX-2) in skin’s surface that can lead to signs of irritation. It is commonly used in cosmetics and personal care products and perfumes and fragrances.
Scientific References:

Safety and Hazards (UN GHS):

1. Harmful if swallowed (H302)
2. Causes skin irritation (H315)
3. Causes serious eye irritation (H319)
4. May cause respiratory irritation (H335)
5. Harmful to aquatic life with long lasting effects (H412)

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