(in 28 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend


Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated. Therapeutic Hydrocortisone is a synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium , and suppresses immune and inflammatory responses. (NCI04)
Scientific References:

Safety and Hazards (UN GHS):

1. Suspected of damaging fertility or the unborn child (H361)
2. Causes damage to organs through prolonged or repeated exposure (H373)

Potential Health Concerns For:

1. Acth-Independent Macronodular Adrenal Hyperplasia (PubMed ID:20529775)
2. Akinetic Mutism (PubMed ID:16682841)
3. Alkalosis (PubMed ID:15090754)
4. Anemia, Hemolytic, Autoimmune (PubMed ID:18565121)
5. Aphasia (PubMed ID:16247223)
6. Apparent mineralocorticoid excess (PubMed ID:7792821)
7. Arrhythmias, Cardiac (PubMed ID:15090754)
8. Atrophy (PubMed ID:4038032)
9. Autonomic Nervous System Diseases (PubMed ID:2948201)
10. Bipolar Disorder (PubMed ID:16682841)
11. Blindness (PubMed ID:4422330)
12. Brain Diseases (PubMed ID:2398367)
13. Cardiomegaly (PubMed ID:4253584)
14. Cleft Palate (PubMed ID:10048155)
15. Cocaine-Related Disorders (PubMed ID:14608241)
16. Cognition Disorders (PubMed ID:10494574)
17. Craniofacial Abnormalities (PubMed ID:17728286)
18. Cushing Syndrome (PubMed ID:7792821)
19. Depressive Disorder (PubMed ID:16157457)
20. Depressive Disorder, Major (PubMed ID:12832253)
21. Dermatitis, Allergic Contact (PubMed ID:11156006)
22. Dermatitis, Contact (PubMed ID:7826093)
23. Drug Hypersensitivity (PubMed ID:1938768)
24. Edema (PubMed ID:6447864)
25. Erectile Dysfunction (PubMed ID:29298510)
26. Essential Hypertension (PubMed ID:7792821)
27. Glucose Intolerance (PubMed ID:12466357)
28. Hearing Loss (PubMed ID:3218493)
29. Heart Arrest (PubMed ID:7380635)
30. Heart Failure (PubMed ID:3026683)
31. Heroin Dependence (PubMed ID:18201294)
32. Hyperplasia (PubMed ID:2462917)
33. Hypersensitivity, Delayed (PubMed ID:10894975)
34. Hypertension (PubMed ID:10694834)
35. Hypertension, Renal (PubMed ID:7792821)
36. Hypertrophy (PubMed ID:2462917)
37. Hypokalemia (PubMed ID:15090754)
38. Insulin Resistance (PubMed ID:17295610)
39. Memory Disorders (PubMed ID:10494574)
40. Meningitis (PubMed ID:10229534)
41. Mental Disorders (PubMed ID:18056188)
42. Muscle Weakness (PubMed ID:10755913)
43. Muscular Atrophy (PubMed ID:4441321)
44. Muscular Diseases (PubMed ID:3750249)
45. Myelitis (PubMed ID:19821538)
46. Nephrosclerosis (PubMed ID:9471316)
47. Neutropenia (PubMed ID:15520061)
48. Obesity (PubMed ID:12466357)
49. Paralysis (PubMed ID:10879076)
50. Paraplegia (PubMed ID:16675057)
51. Paresis (PubMed ID:16247223)
52. Polyuria (PubMed ID:7444917)
53. Prenatal Exposure Delayed Effects (PubMed ID:19473341)
54. Pyelonephritis (PubMed ID:9471316)
55. Radiculopathy (PubMed ID:18549396)
56. Retinal Artery Occlusion (PubMed ID:5047239)
57. Rhabdomyolysis (PubMed ID:10879076)
58. Rosacea (PubMed ID:16384783)
59. Seizures (PubMed ID:14705848)
60. Skin Diseases (PubMed ID:4038032)
61. Stroke (PubMed ID:18996647)
62. Substance Withdrawal Syndrome (PubMed ID:225122)
63. Telangiectasis (PubMed ID:3888708)
64. Urticaria (PubMed ID:6447864)
65. Vascular Diseases (PubMed ID:17295610)
66. Vomiting (PubMed ID:11902300)
67. Weight Gain (PubMed ID:7917157)
68. Weight Loss (PubMed ID:3168935)

Potential Health Benefits For:

1. ACTH Deficiency, Isolated (PubMed ID:16390921)
2. Acute Lung Injury (PubMed ID:19078840)
3. Addison Disease (PubMed ID:16682841)
4. Adrenal Insufficiency (PubMed ID:19691511)
5. Alopecia Areata (PubMed ID:4422330)
6. Anaphylaxis (PubMed ID:12637407)
7. Angioedema (PubMed ID:20547619)
8. Arthritis, Infectious (PubMed ID:983356)
9. Arthritis, Rheumatoid (PubMed ID:983356)
10. Asthma (PubMed ID:15090754)
11. Brain Edema (PubMed ID:2500219)
12. Breast Neoplasms (PubMed ID:6691647)
13. Burkitt Lymphoma (PubMed ID:17609630)
14. Catalepsy (PubMed ID:2999739)
15. Central Nervous System Neoplasms (PubMed ID:11902300)
16. Crohn Disease (PubMed ID:21127120)
17. Diarrhea (PubMed ID:7237001)
18. Drug-Related Side Effects and Adverse Reactions (PubMed ID:9112088)
19. Dyspnea (PubMed ID:81404)
20. Eczema (PubMed ID:3568065)
21. Encephalomyelitis, Autoimmune, Experimental (PubMed ID:5442306)
22. Heart Diseases (PubMed ID:983936)
23. Hemorrhage (PubMed ID:9112088)
24. Hypercalcemia (PubMed ID:8667442)
25. Hyponatremia (PubMed ID:14657545)
26. Hypopituitarism (PubMed ID:15764279)
27. Hypotension (PubMed ID:11919326)
28. Hypotension, Orthostatic (PubMed ID:79115)
29. Leukemia (PubMed ID:11902300)
30. Leukemia, Lymphocytic, Chronic, B-Cell (PubMed ID:11908730)
31. Leukoencephalopathies (PubMed ID:11966594)
32. Long QT Syndrome (PubMed ID:19931775)
33. Lung Diseases (PubMed ID:15995023)
34. Myocardial Ischemia (PubMed ID:303050)
35. Neoplasm Metastasis (PubMed ID:6691647)
36. Otitis Media (PubMed ID:12670280)
37. Phlebitis (PubMed ID:6617280)
38. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (PubMed ID:21064136)
39. Precursor Cell Lymphoblastic Leukemia-Lymphoma (PubMed ID:11019787)
40. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (PubMed ID:20463610)
41. Prostatic Neoplasms (PubMed ID:15520061)
42. Prostatic Neoplasms, Castration-Resistant (PubMed ID:18500220)
43. Purpura, Thrombocytopenic, Idiopathic (PubMed ID:4038421)
44. Recurrence (PubMed ID:7247768)
45. Renal Insufficiency (PubMed ID:8667442)
46. Respiratory Insufficiency (PubMed ID:19078840)
47. Rhabdomyosarcoma (PubMed ID:19821538)
48. Shock (PubMed ID:15942517)
49. Shock, Hemorrhagic (PubMed ID:998147)
50. Shock, Septic (PubMed ID:19691511)
51. Status Asthmaticus (PubMed ID:10689850)
52. Systemic Inflammatory Response Syndrome (PubMed ID:12682474)
53. Thrombophlebitis (PubMed ID:8748367)

User Comments:

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