Estrogens
(in 0 products)
Banned by Gov or classified as a carcinogen by IARC

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend

About:

"Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone , equilin , 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. They promote growth and development of the vagina, uterus, and fallopian tubes, and enlargement of the breasts. Indirectly, they contribute to the shaping of the skeleton, maintenance of tone and elasticity of urogenital structures, changes in the epiphyses of the long bones that allow for the pubertal growth spurt and its termination, growth of axillary and pubic hair, and pigmentation of the nipples and genitals. Decline of estrogenic activity at the end of the menstrual cycle can bring on menstruation, although the cessation of progesterone secretion is the most important factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, estrogen is the primary determinant in the onset of menstruation. Estrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens." [1]
Consultant Review:
- In the American Cancer Society's Cancer Prevention Study II, conducted on 200,000 postmenopausal women, they found that women receiving oral estrogen replacement therapy had a higher death rate from ovarian cancer (1:1.51) compared to those who didn't
- The Women's Health Initiative reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) when they consumed oral estrogen (0.625mg)
Scientific References:
Regulatory References:
1. US California Proposition 65, Chemicals known to the State to Cause Cancer
- Estrogens, steroidal
2. US National Toxicology Program (NTP) Report on Carcinogens
- Estrogens, Steroidal

Safety and Hazards (UN GHS):

1. Causes skin irritation (H315)
2. Causes serious eye irritation (H319)
3. May cause respiratory irritation (H335)
4. May cause cancer (H350)
5. Suspected of causing cancer (H351)
6. May damage fertility or the unborn child (H360)

Potential Health Concerns For:

1. Acne Vulgaris (PubMed ID:4261461)
2. Adenocarcinoma (PubMed ID:12549624)
3. Alopecia (PubMed ID:4261461)
4. Anemia, Megaloblastic (PubMed ID:6520357)
5. Angioedema (PubMed ID:3801312)
6. Angioedemas, Hereditary (PubMed ID:9538488)
7. Anxiety Disorders (PubMed ID:4806735)
8. Blood Coagulation Disorders (PubMed ID:1413345)
9. Blood Platelet Disorders (PubMed ID:1413345)
10. Bone Marrow Diseases (PubMed ID:752088)
11. Bone Resorption (PubMed ID:14751566)
12. Breast Neoplasms (PubMed ID:15352702)
13. Carcinoma, Hepatocellular (PubMed ID:15341023)
14. Carcinoma, Renal Cell (PubMed ID:465965)
15. Cardiomyopathies (PubMed ID:2848969)
16. Cardiovascular Diseases (PubMed ID:1413345)
17. Cerebrovascular Disorders (PubMed ID:9635480)
18. Cholestasis (PubMed ID:6305818)
19. Cholestasis, Intrahepatic (PubMed ID:3442185)
20. Chorea (PubMed ID:574224)
21. Cocaine-Related Disorders (PubMed ID:10869388)
22. Coronary Disease (PubMed ID:718004)
23. Coronary Thrombosis (PubMed ID:5443406)
24. Critical Illness (PubMed ID:16670151)
25. Dementia (PubMed ID:14558187)
26. Depressive Disorder (PubMed ID:4806735)
27. Disease Models, Animal (PubMed ID:23427402)
28. Disseminated Intravascular Coagulation (PubMed ID:752088)
29. Endometrial Neoplasms (PubMed ID:23409030)
30. Endometritis (PubMed ID:752088)
31. Epilepsy (PubMed ID:181243)
32. Fatty Liver (PubMed ID:11929713)
33. Fetal Diseases (PubMed ID:3202672)
34. Galactorrhea (PubMed ID:3465158)
35. Gallbladder Diseases (PubMed ID:16034922)
36. Gallstones (PubMed ID:2298380)
37. Glucose Intolerance (PubMed ID:29175711)
38. Hearing Loss, Sensorineural (PubMed ID:9015429)
39. Heart Defects, Congenital (PubMed ID:443241)
40. Hemolytic-Uremic Syndrome (PubMed ID:6429463)
41. Hemorrhage (PubMed ID:7020014)
42. Hepatic Veno-Occlusive Disease (PubMed ID:8832011)
43. Hereditary Angioedema Type III (PubMed ID:10984376)
44. Hydranencephaly (PubMed ID:3202672)
45. Hypercalcemia (PubMed ID:526949)
46. Hyperkalemia (PubMed ID:10869388)
47. Hyperplasia (PubMed ID:89511)
48. Hyperprolactinemia (PubMed ID:19744546)
49. Hypertension (PubMed ID:185040)
50. Hypertrichosis (PubMed ID:4261461)
51. Insulin Resistance (PubMed ID:29175711)
52. Kidney Neoplasms (PubMed ID:11857771)
53. Lateral Medullary Syndrome (PubMed ID:17344003)
54. Leiomyoma (PubMed ID:23427402)
55. Leukocytosis (PubMed ID:752088)
56. Leukopenia (PubMed ID:752088)
57. Liver Neoplasms, Experimental (PubMed ID:9831364)
58. Mammary Neoplasms, Experimental (PubMed ID:12549624)
59. Mesenteric Ischemia (PubMed ID:718004)
60. Mesenteric Vascular Occlusion (PubMed ID:4032559)
61. Migraine Disorders (PubMed ID:11590960)
62. Myocardial Infarction (PubMed ID:12405240)
63. Myocardial Ischemia (PubMed ID:6933346)
64. Nervous System Diseases (PubMed ID:11424955)
65. Neurasthenia (PubMed ID:4806735)
66. Obesity (PubMed ID:29175711)
67. Osteoporosis (PubMed ID:30639440)
68. Panic Disorder (PubMed ID:3227101)
69. Phlebitis (PubMed ID:866433)
70. Pituitary Diseases (PubMed ID:8164797)
71. Pituitary Neoplasms (PubMed ID:19595700)
72. Porphyria Cutanea Tarda (PubMed ID:5405291)
73. Porphyria, Acute Intermittent (PubMed ID:7776757)
74. Prenatal Exposure Delayed Effects (PubMed ID:830309)
75. Prolactinoma (PubMed ID:10342874)
76. Puerperal Disorders (PubMed ID:453287)
77. Pyelonephritis (PubMed ID:7461697)
78. Rosacea (PubMed ID:4261461)
79. Sexual Dysfunction, Physiological (PubMed ID:22355410)
80. Sinus Thrombosis, Intracranial (PubMed ID:887403)
81. Stroke (PubMed ID:15501350)
82. Thrombocytopenia (PubMed ID:752088)
83. Thromboembolism (PubMed ID:1080277)
84. Thrombosis (PubMed ID:11461176)
85. Toxemia (PubMed ID:752088)
86. Urethral Stricture (PubMed ID:6308871)
87. Vascular Diseases (PubMed ID:1413332)
88. Venous Thromboembolism (PubMed ID:16034922)
89. Venous Thrombosis (PubMed ID:3987273)
90. Weight Gain (PubMed ID:29175711)

Potential Health Benefits For:

1. Bone Diseases, Metabolic (PubMed ID:9379124)
2. Brain Ischemia (PubMed ID:9689481)
3. Coronary Artery Disease (PubMed ID:11815423)
4. Dyskinesia, Drug-Induced (PubMed ID:17909305)
5. Fetal Death (PubMed ID:65916)
6. Hematuria (PubMed ID:16184578)
7. Hypertension, Pulmonary (PubMed ID:14555814)
8. Hypertrophy, Right Ventricular (PubMed ID:14555814)
9. Mood Disorders (PubMed ID:22265196)
10. Neoplasm Metastasis (PubMed ID:4804405)
11. Neoplasms, Experimental (PubMed ID:17876043)
12. Peptic Ulcer (PubMed ID:7053334)
13. Prostatic Neoplasms (PubMed ID:2649197)
14. Status Epilepticus (PubMed ID:16084511)
15. Urinary Bladder Diseases (PubMed ID:15805586)
16. Wounds and Injuries (PubMed ID:11172683)

User Comments:

Subtotal: $0.00 HKD