E578; Calcium Gluconate
(in 1,189 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend


1. Acidity Regulator / Buffering Agent - Changes or maintains the acidity or basicity of food/cosmetics.
2. Binder / Stabilizer - Retains the physical characteristics of food/cosmetics and ensure the mixture remains in an even state.
3. Dietary / Nutritional Supplement - Vitamins, minerals, proteins, fatty acids or probiotics that improves nutritional intake
4. Drug / Medicine - Treats, alleviates, cures, or prevents sickness. As officially declared by a governmental drug/medicine regulatory body
Calcium Gluconate is the gluconate salt of calcium, which can use as a mineral supplement and medication. An element or mineral necessary for normal nerve, muscle, and cardiac function, calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers.
As a food additive (E578), calcium gluconate is found in fruit, honey, tea and wine. It can also be produced by the fermentation of glucose with certain moulds, to produce colourless crystals that are very soluble in water. It is used as a firming agent, buffer, sequestrant, acidity regulator, artificial sweetener base, and as a mineral supplement in food. Used in chewing gum, lozenges, breath fresheners, dietary supplements, and body building formulas.
Dietary supplement for Calcium.
It is approved to use as food additive in EU and generally recognized as safe food substance in US.
Scientific References:
Regulatory References:
1. EU Approved Food Additive [2018]
- E578
2. Japan’s List of Designated Food Additives under Article 10 of the Food Sanitation Act
- Calcium Gluconate
3. WHO Model List of Essential Medicines [2019]
- calcium gluconate
4. US FDA Generally Recognized As Safe (GRAS) Food Substances (21 CFR 184) [2017]
- § 184.1199 - Calcium gluconate

Safety and Hazards (UN GHS):

1. Harmful if swallowed (H302)

Potential Health Concerns For:

1. Cardiomyopathies (PubMed ID:19289450)
2. Growth Disorders (PubMed ID:14968361)
3. Heart Arrest (PubMed ID:19289450)
4. Hypercalcemia (PubMed ID:14968361)
5. Hypercalciuria (PubMed ID:6786090)
6. Muscle Hypotonia (PubMed ID:14968361)
7. Nephrolithiasis (PubMed ID:6786090)
8. Pulmonary Embolism (PubMed ID:19289450)
9. Tachycardia, Sinus (PubMed ID:678101)
10. Thrombosis (PubMed ID:19289450)

Potential Health Benefits For:

1. Ataxia (PubMed ID:22974967)
2. Atrioventricular Block (PubMed ID:7388371)
3. Bronchopulmonary Dysplasia (PubMed ID:6786090)
4. Drug Overdose (PubMed ID:11914425)
5. Hypotension (PubMed ID:15359206)
6. Hypoxia (PubMed ID:15359206)
7. Long QT Syndrome (PubMed ID:15953230)
8. Muscular Diseases (PubMed ID:6849511)
9. Myasthenia Gravis (PubMed ID:19587486)
10. Nerve Degeneration (PubMed ID:21981408)
11. Neuromuscular Manifestations (PubMed ID:8193107)
12. Neurotoxicity Syndromes (PubMed ID:19914363)
13. Pain, Postoperative (PubMed ID:6849511)
14. Paralysis (PubMed ID:8193107)
15. Peripheral Nervous System Diseases (PubMed ID:21981408)
16. Pulmonary Edema (PubMed ID:17507140)
17. Tachycardia, Supraventricular (PubMed ID:6499292)
18. Tetany (PubMed ID:18653914)
19. Torsades de Pointes (PubMed ID:7388371)

User Comments:

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