E518; Magnesium Sulfate
(in 7,083 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend


1. Dietary / Nutritional Supplement - Vitamins, minerals, proteins, fatty acids or probiotics that improves nutritional intake
2. Drug / Medicine - Treats, alleviate, cure, or prevents sickness. As officially declared by a governmental drug/medicine regulatory body
Magnesium sulfate is a small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. Magnesium sulfate is gaining popularity as an initial treatment in the management of various dysrhythmias, particularly torsades de pointes, and dyrhythmias secondary to TCA overdose or digitalis toxicity.
It is not approved to use as food additive (E518) in EU.
Scientific References:
Regulatory References:
1. E-numbers which are not found in EU FOOD
2. Japan’s List of Designated Food Additives under Article 10 of the Food Sanitation Act
- Magnesium Sulfate
3. Canada List of Permitted Food Additives
- List 8 - Magnesium Sulphate
4. US FDA Generally Recognized As Safe (GRAS) Food Substances (21 CFR 184) [2017]
- § 184.1443 - Magnesium sulfate

Safety and Hazards (UN GHS):

1. Harmful if swallowed (H302)
2. Harmful in contact with skin (H312)
3. Causes skin irritation (H315)
4. Causes serious eye irritation (H319)
5. Harmful if inhaled (H332)

Potential Health Concerns For:

1. Anemia (PubMed ID:9617735)
2. Apnea (PubMed ID:19561013)
3. Atrial Fibrillation (PubMed ID:8300011)
4. Bradycardia (PubMed ID:10755794)
5. Brain Injuries (PubMed ID:19204407)
6. Calcinosis (PubMed ID:8271715)
7. Cerebral Hemorrhage (PubMed ID:12066082)
8. Cerebral Palsy (PubMed ID:10909948)
9. Chest Pain (PubMed ID:1733214)
10. Coma (PubMed ID:12910986)
11. Delirium (PubMed ID:12190013)
12. Diplopia (PubMed ID:2256494)
13. Dizziness (PubMed ID:11713998)
14. Drug Overdose (PubMed ID:12910986)
15. Eclampsia (PubMed ID:2589455)
16. Eyelid Diseases (PubMed ID:20864066)
17. Gait Disorders, Neurologic (PubMed ID:9617734)
18. Heart Arrest (PubMed ID:19561013)
19. Heart Diseases (PubMed ID:1733214)
20. Hyperalgesia (PubMed ID:19715604)
21. Hypesthesia (PubMed ID:19715604)
22. Hypocalcemia (PubMed ID:12190013)
23. Hypokalemia (PubMed ID:7828395)
24. Hypotension (PubMed ID:10654500)
25. Hypothermia (PubMed ID:9764667)
26. Infant, Newborn, Diseases (PubMed ID:12053081)
27. Kidney Diseases (PubMed ID:12053081)
28. Leukomalacia, Periventricular (PubMed ID:12066082)
29. Muscle Weakness (PubMed ID:20864066)
30. Muscular Diseases (PubMed ID:11730501)
31. Myasthenia Gravis (PubMed ID:2385256)
32. Nausea (PubMed ID:11713998)
33. Nephritis, Interstitial (PubMed ID:9617735)
34. Neuromuscular Manifestations (PubMed ID:15625263)
35. Organophosphate Poisoning (PubMed ID:19504058)
36. Pain (PubMed ID:19459639)
37. Paralysis (PubMed ID:17244984)
38. Paresis (PubMed ID:7731416)
39. Paresthesia (PubMed ID:3631562)
40. Pre-Eclampsia (PubMed ID:2589455)
41. Quadriplegia (PubMed ID:2385256)
42. Respiration Disorders (PubMed ID:9617734)
43. Respiratory Insufficiency (PubMed ID:18441730)
44. Seizures (PubMed ID:9617734)
45. Stupor (PubMed ID:17643282)
46. Tonic Pupil (PubMed ID:2256494)
47. Tremor (PubMed ID:12475575)
48. Urinary Calculi (PubMed ID:9360190)
49. Ventricular Dysfunction (PubMed ID:9234661)
50. Ventricular Fibrillation (PubMed ID:1582316)
51. Vomiting (PubMed ID:11713998)
52. Weight Gain (PubMed ID:9617735)

Potential Health Benefits For:

1. Anemia, Hypochromic Microcytic, With Iron Overload (PubMed ID:22561110)
2. Angina Pectoris, Variant (PubMed ID:1733214)
3. Arrhythmias, Cardiac (PubMed ID:15582773)
4. Brain Edema (PubMed ID:15519365)
5. Drug-Related Side Effects and Adverse Reactions (PubMed ID:7837314)
6. Dyskinesia, Drug-Induced (PubMed ID:12895461)
7. Fasciculation (PubMed ID:17876916)
8. Fetal Growth Retardation (PubMed ID:16690511)
9. Hepatic Encephalopathy (PubMed ID:3768664)
10. Hyperkalemia (PubMed ID:17876916)
11. Hypertension (PubMed ID:11167434)
12. Hypertension, Pulmonary (PubMed ID:7731416)
13. Hypomagnesemia 2, renal (PubMed ID:3082455)
14. Long QT Syndrome (PubMed ID:14513929)
15. Magnesium Deficiency (PubMed ID:6069279)
16. Myoclonus (PubMed ID:16115978)
17. Nerve Degeneration (PubMed ID:21981408)
18. Obstetric Labor, Premature (PubMed ID:10565464)
19. Pain, Postoperative (PubMed ID:18557167)
20. Peripheral Nervous System Diseases (PubMed ID:21981408)
21. Proteinuria (PubMed ID:17643282)
22. Restless Legs Syndrome (PubMed ID:17557494)
23. Tachycardia (PubMed ID:6842789)
24. Tachycardia, Ventricular (PubMed ID:1582316)
25. Tetanus (PubMed ID:9709153)
26. Tetany (PubMed ID:3082455)
27. Torsades de Pointes (PubMed ID:1363741)

User Comments:

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