Diazolidinylurea
(in 13,654 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend

About:

Functions:
1. Antimicrobial Preservative - Actively kills and inhibits the growth of unwanted microorganisms which may be harmful.
2. Drug / Medicine - Used to treat, alleviate, cure or prevent sickness. As officially declared by a governmental drug/medicine regulatory body
3. Preservative - Prevents and inhibits the growth of unwanted microorganisms which may be harmful
May release Formaldehyde under aqueous conditions, such as contacting with water or in humid conditions.[2]
Please see 'Formaldehyde' for further details.
Recent Findings:
- 150ppm of formaldehyde can be recovered from shampoos using 0.1% diazolidinylurea and up to 740ppm can be recovered from a concentration of 0.8%. In protein-based shampoos, the formaldehyde recovered is lower as formaldehyde can be complexed (binded) to the protein, preventing its release.
- As for environmental impacts, diazolidinylurea can also be used to promote tissue healing in "salt water, tropical, and cold water fish". [3]
- In a separate study, diazolidinylurea has proven its effectiveness as an anti-fungal and anti-bacterial agent, especially when combined with other antimicrobial compounds such as N-chloramines and parabens. [4]
Scientific References:
2. Investigation on formaldehyde release from preservatives in cosmetics (Int J Cosmet Sci. 2015 Oct;37(5):474-8. doi: 10.1111/ics.12212)
3. Final Report on the Safety Assessment of Diazolidinyl Urea (Int. J. Toxicol. 1990 March;9(2):229-245. doi: 10.3109/10915819009078735)
4. Antimicrobial Activities of N-Chloramines and Diazolidinyl Urea (Appl. Environ. Microbiol. Feb 1985, 49 (2) 370-373)
Regulatory References:
1. EU CosIng Annex V, PRESERVATIVES ALLOWED IN COSMETIC PRODUCTS [2017]
- Ref: V/46
2. Cosmetic Ingredient Review
- Diazolidinyl Urea

Safety and Hazards (UN GHS):

1. May cause an allergic skin reaction (H317)
2. Causes serious eye irritation (H319)
3. Harmful to aquatic life with long lasting effects (H412)

Potential Health Concerns For:

1. Dermatitis, Allergic Contact (PubMed ID:16426289)
2. Dermatitis, Atopic (PubMed ID:15218738)
3. Eczema (PubMed ID:16426289)
4. Erythema (PubMed ID:16426289)

User Comments:

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