75% and >95% respectively). [10] It is feared that this may lead to hepatotoxicity which has already been observed in rats. [10] However, separate studies have shown that this is due to the species differences in how coumarin is metabolized within the body. Therefore "species differences in coumarin hepatotoxicity appear to be metabolism-mediated" and that "liver toxicity in patients receiving relatively high daily doses of coumarin is very rare". [11] Animal toxicity tests on coumarin conducted on dogs and gibbons showed far less toxicity with no evidence of teratogenicity or mutagenicity. [12]
EU CosIng Annex III Restriction Information:
Regulation:
(EC) No 1223/2009
Regulated By:
2003/15/EC
Annex/Ref#:
III/77
Other:
The presence of the substance must be indicated in the list of ingredients referred to in Article 19(1)g when its concentration exceeds:
- 0.001% in leave-on products
- 0.01% in rinse-off products
SCCS opinions:
0450/01 - Memorandum on the SCCNFP Opinion concerning Fragrance Allergy
0673/03 - Opinion concerning Essential Oils
0935/05 - Opinion on Coumarin (sensitisation only)
0017/98 - Opinion concerning Fragrance Allergy in Consumers - A Review of the Problem -
Analysis of the need for appropriate Consumer Information and Identification of Consumer Allergens
0202/99 - Opinion concerning the Interim Position on Fragrance Allergy
" />
75% and >95% respectively). [10] It is feared that this may lead to hepatotoxicity which has already been observed in rats. [10] However, separate studies have shown that this is due to the species differences in how coumarin is metabolized within the body. Therefore "species differences in coumarin hepatotoxicity appear to be metabolism-mediated" and that "liver toxicity in patients receiving relatively high daily doses of coumarin is very rare". [11] Animal toxicity tests on coumarin conducted on dogs and gibbons showed far less toxicity with no evidence of teratogenicity or mutagenicity. [12]
EU CosIng Annex III Restriction Information:
Regulation:
(EC) No 1223/2009
Regulated By:
2003/15/EC
Annex/Ref#:
III/77
Other:
The presence of the substance must be indicated in the list of ingredients referred to in Article 19(1)g when its concentration exceeds:
- 0.001% in leave-on products
- 0.01% in rinse-off products
SCCS opinions:
0450/01 - Memorandum on the SCCNFP Opinion concerning Fragrance Allergy
0673/03 - Opinion concerning Essential Oils
0935/05 - Opinion on Coumarin (sensitisation only)
0017/98 - Opinion concerning Fragrance Allergy in Consumers - A Review of the Problem -
Analysis of the need for appropriate Consumer Information and Identification of Consumer Allergens
0202/99 - Opinion concerning the Interim Position on Fragrance Allergy
" />
Potential Health Concerns潛在的健康安全潜在的健康安全Posibles problemas de saludProblèmes de santé potentielsPotenziali problemi di salute잠재적 건강 문제潜在的な健康上の懸念
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Potential Health Benefits潛在的健康益處潜在的健康益处Beneficios potenciales para la saludAvantages potentiels pour la santéPotenziali benefici per la salute잠재적 건강상의 이점潜在的な健康上の利点
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Hazard Codes危險代碼危险代码Códigos de peligroCodes de dangerCodici di pericolo위험 코드危険コード