Chlorhexidine Digluconate; Chlorhexidine Gluconate
(in 897 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend


1. Antiseptic / Disinfectant - Prevents growth of unwanted microorganisms.
2. Drug / Medicine - Treats, alleviates, cures, or prevents sickness. As officially declared by a governmental drug/medicine regulatory body
Chlorhexidine, a topical antimicrobial agent, is bactericidal. Because of its positive charge, the chlorhexidine molecule reacts with the microbial cell surface to destroy the integrity of the cell membrane. This novel mechanism of action makes it highly unlikely for the development of bacterial resistance. Chlorhexidine is a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since Gram-positive bacteria are more negatively charged, they are more sensitive to this agent. [1]
Recent Findings:
Chlorhexidine digluconate is commonly found in Cedium Chlorhexidine. It is often used as a skin disinfectant before surgery.
Scientific References:
Regulatory References:
1. Japan - Ministry of Health, Labour and Welfare - Restricted Ingredients
- Chlorhexidine gluconate
2. FDA Unapproved
- 81 FR 61106
- Ref: V/42

Safety and Hazards (UN GHS):

1. Toxic if swallowed (H301)
2. Harmful if swallowed (H302)
3. Causes skin irritation (H315)
4. May cause an allergic skin reaction (H317)
5. Causes serious eye damage (H318)
6. Causes serious eye irritation (H319)
7. May cause allergy or asthma symptoms or breathing difficulties if inhaled (H334)
8. May cause respiratory irritation (H335)
9. Very toxic to aquatic life (H400)
10. Very toxic to aquatic life with long lasting effects (H410)
11. Toxic to aquatic life with long lasting effects (H411)

Potential Health Concerns For:

1. Anaphylaxis (PubMed ID:10321611)
2. Chemical and Drug Induced Liver Injury (PubMed ID:145039)
3. Cystitis (PubMed ID:1009330)
4. Drug Hypersensitivity (PubMed ID:10321611)
5. Eye Injuries (PubMed ID:33358762)
6. Gingivitis (PubMed ID:9759061)
7. Glossitis (PubMed ID:18245686)
8. Pain (PubMed ID:16566965)
9. Periodontitis (PubMed ID:9759061)
10. Pharyngitis (PubMed ID:18245686)
11. Renal Insufficiency (PubMed ID:145039)
12. Taste Disorders (PubMed ID:18245686)
13. Tooth Discoloration (PubMed ID:18245686)
14. Urination Disorders (PubMed ID:16566965)

User Comments:

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