Chlorhexidine Digluconate; Chlorhexidine Gluconate

(in 894 products)

1. Antiseptic / Disinfectant - Prevents growth of unwanted microorganisms.

2. Drug / Medicine - Treats, alleviates, cures, or prevents sickness. As officially declared by a governmental drug/medicine regulatory body

Chlorhexidine, a topical antimicrobial agent, is bactericidal. Because of its positive charge, the chlorhexidine molecule reacts with the microbial cell surface to destroy the integrity of the cell membrane. This novel mechanism of action makes it highly unlikely for the development of bacterial resistance. Chlorhexidine is a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since Gram-positive bacteria are more negatively charged, they are more sensitive to this agent. [1]

Chlorhexidine digluconate is commonly found in Cedium Chlorhexidine. It is often used as a skin disinfectant before surgery.

1. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/9552079

1. Japan - Ministry of Health, Labour and Welfare - Restricted Ingredients

- Chlorhexidine gluconate

2. FDA Unapproved

- 81 FR 61106

3. EU CosIng Annex V, PRESERVATIVES ALLOWED IN COSMETIC PRODUCTS [2017]

- Ref: V/42