Butylated Hydroxyanisole
(in 1,628 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend

About:

Functions:
1. Antioxidant - Reduces oxidation to prevent the formation of free radicals which may be harmful to health.
2. Fragrance / Fragrance Component - Provides or enhances a particular smell or odor.
3. Preservative - Prevents and inhibits the growth of unwanted microorganisms which may be harmful
Butylated Hydroxyanisole is a waxy solid used as a food additive with the E number E320 and mostly used in edible oils, chewing gum, fats, margarine, nuts, instant potato products, and polyethylene food wrappers. Butylated Hydroxyanisole is a widely used synthetic antioxidant in foods, cosmetics and pharmaceuticals mainly to preserve fats and oils. Butylated Hydroxyanisole is reasonably anticipated to be a human carcinogen. [1]
It is approved to use as food additive in EU and generally recognized as safe food substance in US.
Scientific References:
Regulatory References:
1. US California Proposition 65, Chemicals known to the State to Cause Cancer
- Butylated hydroxyanisole
2. WHO International Agency for Research on Cancer (IARC) - Group 2B [2018]
- Butylated hydroxyanisole (BHA)
3. US FDA Food Additives Status List [2018]
- BHA (butylated hydroxyanisole)
4. EU Approved Food Additive [2018]
- E320
5. Japan’s List of Designated Food Additives under Article 10 of the Food Sanitation Act
- Butylated Hydroxyanisole
6. US FDA Generally Recognized As Safe (GRAS) (21 CFR 182) [2017]
- § 182.3169 - Butylated hydroxyanisole
7. International Fragrance Association Transparency List [2015]
- Butylated hydroxyanisole

Safety and Hazards (UN GHS):

1. Harmful if swallowed (H302)
2. Harmful in contact with skin (H312)
3. Causes skin irritation (H315)
4. Causes serious eye damage (H318)
5. Causes serious eye irritation (H319)
6. Harmful if inhaled (H332)
7. May cause respiratory irritation (H335)
8. May cause cancer (H350)
9. Suspected of causing cancer (H351)
10. Toxic to aquatic life with long lasting effects (H411)

Potential Health Concerns For:

1. Adenoma (PubMed ID:3102426)
2. Carcinoma, Renal Cell (PubMed ID:6142774)
3. Carcinoma, Squamous Cell (PubMed ID:3804118)
4. Dermatitis, Atopic (PubMed ID:15218738)
5. Dermatitis, Contact (PubMed ID:6221686)
6. Hepatomegaly (PubMed ID:28108177)
7. Hyperplasia (PubMed ID:23535288)
8. Liver Neoplasms, Experimental (PubMed ID:3102426)
9. Necrosis (PubMed ID:16532269)
10. Papilloma (PubMed ID:2276703)
11. Parakeratosis (PubMed ID:23535288)
12. Precancerous Conditions (PubMed ID:3802071)
13. Stomach Neoplasms (PubMed ID:1399818)
14. Urinary Bladder Neoplasms (PubMed ID:1399818)

Potential Health Benefits For:

1. Acute Lung Injury (PubMed ID:1559913)
2. Breast Neoplasms (PubMed ID:23027624)
3. Carcinoma, Hepatocellular (PubMed ID:6142774)
4. Chemical and Drug Induced Liver Injury (PubMed ID:6515131)
5. Colitis (PubMed ID:30844440)
6. Drug-Related Side Effects and Adverse Reactions (PubMed ID:6506766)
7. Heart Diseases (PubMed ID:8910858)
8. Hypertension, Pulmonary (PubMed ID:1559913)
9. Learning Disorders (PubMed ID:25242404)
10. Liver Diseases, Parasitic (PubMed ID:3005948)
11. Liver Neoplasms (PubMed ID:10503899)
12. Mammary Neoplasms, Animal (PubMed ID:19526586)
13. Memory Disorders (PubMed ID:25242404)
14. Neoplasms, Experimental (PubMed ID:8068195)
15. Nerve Degeneration (PubMed ID:16403784)
16. Pancreatic Neoplasms (PubMed ID:1906380)

User Comments:

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