Aminobutyric Acid; Gamma-Aminobutyric Acid
(in 355 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend


1. Antioxidant - Reduces oxidation to prevent the formation of free radicals which may be harmful to health.
2. Dietary / Nutritional Supplement - Vitamins, minerals, proteins, fatty acids or probiotics that improves nutritional intake
3. Flavor / Flavoring / Flavor Enhancer - Provides or enhances a particular taste or smell.
Gamma-Aminobutyric Acid is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. Gamma-aminobutyric acid ( GABA ), converted from the principal excitatory neurotransmitter glutamate in the brain, plays a role in regulating neuronal excitability by binding to its receptors, GABA-A and GABA-B, and thereby causing ion channel opening, hyperpolarization and eventually inhibition of neurotransmission. [1]
GABA, when taken by mouth, is used for relieving anxiety, improving mood, reducing symptoms of premenstrual syndrome (PMS), and treating attention deficit-hyperactivity disorder (ADHD). It is also used for promoting lean muscle growth, burning fat, stabilizing blood pressure, and relieving pain. [2]
Scientific References:
Regulatory References:
1. CANADA Natural Health Products Ingredients Database [2018]
- 4-Aminobutanoic acid

Safety and Hazards (UN GHS):

1. Causes skin irritation (H315)
2. Causes serious eye irritation (H319)
3. May cause respiratory irritation (H335)

Potential Health Concerns For:

1. Ataxia (PubMed ID:19747469)
2. Bradycardia (PubMed ID:1451572)
3. Catalepsy (PubMed ID:6771794)
4. Catatonia (PubMed ID:2823166)
5. Cocaine-Related Disorders (PubMed ID:15135161)
6. Epilepsy (PubMed ID:19474175)
7. Hemiplegia (PubMed ID:3683725)
8. Hypertension (PubMed ID:10524271)
9. Hypotension (PubMed ID:1451572)
10. Manganese Poisoning (PubMed ID:18771689)
11. Movement Disorders (PubMed ID:2727012)
12. Schizophrenia (PubMed ID:18757185)
13. Seizures (PubMed ID:9030893)
14. Status Epilepticus (PubMed ID:1969357)
15. Substance Withdrawal Syndrome (PubMed ID:10690749)
16. Tachycardia (PubMed ID:2541852)

Potential Health Benefits For:

1. Drug-Related Side Effects and Adverse Reactions (PubMed ID:6872331)
2. Glucose Metabolism Disorders (PubMed ID:25456265)
3. Stomach Ulcer (PubMed ID:28456544)

User Comments:

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