Adenosine

(in 5,480 products)

1. Biologics - Biological components such as amino acids and its derivatives which modifies certain functions

Adenosine is an endogenous nucleoside occurring in all cells of the body and is not chemically related to other antiarrhythmic drugs. Adenosine may exert its pharmacologic effects by activation of purine (cell surface A 1 and A 2 adenosine ) receptors, as well as relax vascular smooth muscles through the reduction in calcium uptake by inhibition of slow inward calcium current and activation of adenylate cyclase in smooth muscle cells. Adenosine may reduce vascular tone by modulation of sympathetic neurotransmission. The drug also has negative chronotropic, dromotropic, and inotropic effects on the heart by slowing conduction time throught he AV node and interrupting AV nodal reentry pathways. Adenosine is a potent vasodilator in most vascular beds, but vasoconstriction is produced in renal afferent arterioles and hepatic veins. The drug produces a net mild to moderate reduction in systolic, diastolic, and mean arterial blood pressure and a reflex increase in heart rate. Adenosine is antagonized competitively by methylxanthines such as caffeine and theophylline , and potentiated by blockers of nucleoside transport such as dipyridamole . Adenosine is not blocked by atropine . Adenosine is a ribonucleoside comprised of adenine bound to ribose , with vasodilatory, antiarrhythmic and analgesic activities. Phosphorylated forms of adenosine play roles in cellular energy transfer, signal transduction and the synthesis of RNA.

1. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/60961

1. South Korea - Ministry of Food and Drug Safety - Prohibited/Restricted Chemicals

- Ref: 386

2. Cosmetic Ingredient Review

- Adenosine