2-Bromo-2-Nitropropane-1,3-Diol; Bronopol
(in 910 products)

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend


1. Antimicrobial Preservative - Actively kills and inhibits the growth of unwanted microorganisms which may be harmful.
2. Preservative - Prevents and inhibits the growth of unwanted microorganisms which may be harmful
"Bronopol, or 2-Bromo-2-nitro-1,3-propanediol, is an inorganic compound with wide-spectrum antimicrobial properties. First synthesized in 1897, bronopol was primarily used as a preservative for pharmaceuticals and was registered in the United States." [1]
May release Formaldehyde under aqueous conditions, such as contacting with water or in humid conditions. [2]
Please see 'Formaldehyde' for further details.
Scientific References:
2. Investigation on formaldehyde release from preservatives in cosmetics (Int J Cosmet Sci. 2015 Oct;37(5):474-8. doi: 10.1111/ics.12212)
Regulatory References:
1. South Korea - Ministry of Food and Drug Safety - Prohibited/Restricted Chemicals
- Ref: 1
2. CANADA INGREDIENT HOTLIST, List of Ingredients that are Restricted for Use in Cosmetic Products [2019]
- 2-Bromo-2-nitropropane-1,3-diol
- Ref: V/21

Safety and Hazards (UN GHS):

1. Harmful if swallowed (H302)
2. Harmful if swallowed or in contact with skin (H302+H312)
3. Fatal in contact with skin (H310)
4. Harmful in contact with skin (H312)
5. Causes skin irritation (H315)
6. Causes serious eye damage (H318)
7. Fatal if inhaled (H330)
8. May cause respiratory irritation (H335)
9. Causes damage to organs through prolonged or repeated exposure (H373)
10. Very toxic to aquatic life (H400)
11. Toxic to aquatic life (H401)
12. Toxic to aquatic life with long lasting effects (H411)

Potential Health Concerns For:

1. Dermatitis, Allergic Contact (PubMed ID:15059100)
2. Dermatitis, Atopic (PubMed ID:15218738)
3. Dermatitis, Contact (PubMed ID:6221686)

User Comments:

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