Drospirenone(in 0 products)
Banned by Gov or classified as a carcinogen by IARC
Banned by Gov or classified as a carcinogen by IARC
Potential Risk Index®:
About:
Functions:
1. Biologics - Biological components such as amino acids and its derivatives which modifies certain functions
2. Drug / Medicine - Treats, alleviates, cures, or prevents sickness. As officially declared by a governmental drug/medicine regulatory body
Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone . As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin- aldosterone system, and is not androgenic. Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity. Drospirenone binds to the progesterone receptor, the resulting complex becomes activated and binds to specific sites on DNA. This results in a suppression of LH activity and an inhibition of ovulation as well as an alteration in the cervical mucus and endometrium. This leads to an increased difficulty of sperm entry into the uterus and implantation. This drug is used in oral contraceptives.
Scientific References:
1. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/68873
Regulatory References:
1. EU CosIng Annex II, SUBSTANCES PROHIBITED IN COSMETIC PRODUCTS [2017]
- Ref: II/194
2. South Korea - Ministry of Food and Drug Safety - Prohibited/Restricted Chemicals
- Ref: 1187
Safety and Hazards (UN GHS):
1. Harmful if swallowed (H302)
2. Harmful in contact with skin (H312)
3. Harmful if inhaled (H332)
4. Suspected of causing cancer (H351)
5. May damage fertility or the unborn child (H360)
6. May cause harm to breast-fed children (H362)
7. Toxic to aquatic life with long lasting effects (H411)
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