Cannabis; Cannabidiol (CBD)
(in 39 products)
Banned by Gov or classified as a carcinogen by IARC

Potential Risk Index®:

ISCE InhaleISCE SwallowISCE ContactISCE Environment
PRI Legend

About:

Functions:
1. Antioxidant - Reduces oxidation to prevent the formation of free radicals which may be harmful to health.
2. Drug / Medicine - Treats, alleviates, cures, or prevents sickness. As officially declared by a governmental drug/medicine regulatory body
Cannabidiol is a phytocannabinoid derived from Cannabis species, which is devoid of psychoactive activity, with analgesic, anti-inflammatory, antineoplastic and chemopreventive activities. Upon administration, cannabidiol (CBD) exerts its anti-proliferative, anti-angiogenic and pro-apoptotic activity through various mechanisms, which likely do not involve signaling by cannabinoid receptor 1 (CB1), CB2, or vanilloid receptor 1. CBD stimulates endoplasmic reticulum (ER) stress and inhibits AKT/mTOR signaling, thereby activating autophagy and promoting apoptosis. In addition, CBD enhances the generation of reactive oxygen species (ROS), which further enhances apoptosis. This agent also upregulates the expression of intercellular adhesion molecule 1 (ICAM-1) and tissue inhibitor of matrix metalloproteinases-1 (TIMP1) and decreases the expression of inhibitor of DNA binding 1 (ID-1). This inhibits cancer cell invasiveness and metastasis. CBD may also activate the transient receptor potential vanilloid type 2 (TRPV2), which may increase the uptake of various cytotoxic agents in cancer cells. The analgesic effect of CBD is mediated through the binding of this agent to and activation of CB1. [1]
Cannabidiol (CBD) is an active ingredient found in cannabis (marijuana). According to the World Health Organization (WHO), CBD is not classified as a psychoactive substance, and does not cause a "high": "According to a report from the World Health Organization, "In humans, CBD exhibits no effects indicative of any abuse or dependence potential…. To date, there is no evidence of public health related problems associated with the use of pure CBD."" The Agriculture Improvement Act of 2018 (2018 Farm Bill) made hemp legal in the US.
CBD has been shown in animal studies and trial research in humans to help with anxiety, insomnia, chronic pain, inflammation, and the reduction of addiction to other drugs. (https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476)
Recent Findings:
The Hong Kong Government, Secretary for Security, Mr John Lee of the Legislative Council has stated:
Tetrahydro-cannabinol (THC) is a cannabinoid present in cannabis plants and is a dangerous drug controlled under the Dangerous Drugs Ordinance (Cap. 134). Any products (including any food products and drinks) that contain THC are also controlled under Cap. 134.
Under Cap. 134, trafficking in dangerous drugs, or illicitly importing to and exporting from Hong Kong, procuring, supplying, manufacturing, or dealing in or with dangerous drugs, constitutes a criminal offence. The maximum penalty is life imprisonment and a fine of $5 million. Illicitly possessing, or smoking, inhaling, ingesting or injecting dangerous drugs is subject to a maximum penalty of imprisonment for seven years and a fine of $1 million.
Cannabidiol (CBD) is another cannabinoid present in cannabis plants but is not a dangerous drug controlled under Cap. 134. For pharmaceutical products containing CBD but not any dangerous drugs, the products must be registered with the Pharmacy and Poisons Board (the Board) in accordance with the requirements under the Pharmacy and Poisons Ordinance (Cap. 138) before it can be sold or distributed. Manufacturers, importers or distributors of the pharmaceutical products must also obtain relevant licences from the Board. In addition, for importing pharmaceutical products, an import licence must be obtained under the Import and Export Ordinance (Cap. 60). At present, no registered pharmaceutical product contains CBD.
Regarding food products or drinks containing CBD, since it is difficult to extract pure CBD, the food products and drinks concerned may highly likely contain other cannabinoids controlled under Cap. 134 (such as THC). The local food trade should avoid importing or manufacturing products concerned lest they would breach the law.
Scientific References:
Regulatory References:
1. EU CosIng Annex II, SUBSTANCES PROHIBITED IN COSMETIC PRODUCTS [2017]
- Ref: II/306, Cannabis and Cannabis resin; Cannabis sativa, ext.
2. CANADA INGREDIENT HOTLIST, List of Ingredients that are Prohibited for Use in Cosmetic Products [2019]
- Cannabis, as defined in subsection 2(1) of the Cannabis Act (see the Cannabis Exemption (Food and Drugs Act) Regulations for details) - superceded by Cannabis Exemption (Food and Drugs Act)
3. Hong Kong Cap. 138A Pharmacy and Poisons Regulations - Schedule 1
- Cannabidiol; its salts; when contained in pharmaceutical products
- Cannabinol and its tetrahydro derivatives; their 3-alkyl homologues; any ester or ether of any substance falling within this item
- Cannabis; the resin of cannabis; extracts of cannabis; tinctures of cannabis; cannabin tennate
-

Safety and Hazards (UN GHS):

1. Toxic if swallowed (H301)
2. Harmful if swallowed (H302)
3. Suspected of damaging fertility or the unborn child (H361)
4. May cause long lasting harmful effects to aquatic life (H413)

Potential Health Concerns For:

1. Abnormalities, Drug-Induced (PubMed ID:29106691)
2. Body Weight (PubMed ID:31052254)
3. Bradycardia (PubMed ID:30002406)
4. Craniofacial Abnormalities (PubMed ID:31690747)
5. Drug-Related Side Effects and Adverse Reactions (PubMed ID:31530885)
6. Embryo Loss (PubMed ID:30002406)
7. Feeding and Eating Disorders (PubMed ID:31052254)
8. Fetal Weight (PubMed ID:31690747)
9. Heart Diseases (PubMed ID:33338514)
10. Hepatomegaly (PubMed ID:31052254)
11. Holoprosencephaly (PubMed ID:31690747)
12. Hyperinsulinism (PubMed ID:30382123)
13. Hypotension (PubMed ID:3793381)
14. Hypothermia (PubMed ID:31336109)
15. Lethargy (PubMed ID:31052254)
16. Micronuclei, Chromosome-Defective (PubMed ID:30341733)
17. Motor Skills Disorders (PubMed ID:28807673)
18. Musculoskeletal Abnormalities (PubMed ID:30002406)
19. Neural Tube Defects (PubMed ID:31690747)
20. Ocular Hypertension (PubMed ID:30550613)
21. Poisoning (PubMed ID:23552853)
22. Prenatal Exposure Delayed Effects (PubMed ID:30594692)
23. Prenatal Injuries (PubMed ID:31690747)
24. Seizures (PubMed ID:10605059)
25. Xerostomia (PubMed ID:3793381)

Potential Health Benefits For:

1. Alcoholic Intoxication (PubMed ID:31074060)
2. Alcoholism (PubMed ID:28194850)
3. Alzheimer Disease (PubMed ID:27567873)
4. Anxiety Disorders (PubMed ID:31063743)
5. Ataxia (PubMed ID:30074247)
6. Bipolar Disorder (PubMed ID:19939866)
7. Bone Resorption (PubMed ID:28479140)
8. Catalepsy (PubMed ID:28807673)
9. Chemical and Drug Induced Liver Injury (PubMed ID:28935932)
10. Cocaine-Related Disorders (PubMed ID:33427014)
11. Cognition Disorders (PubMed ID:21350020)
12. Disease Models, Animal (PubMed ID:27567873)
13. Dyslipidemias (PubMed ID:31499052)
14. Dystonia (PubMed ID:3793381)
15. Encephalomyelitis, Autoimmune, Experimental (PubMed ID:30123217)
16. Epilepsies, Myoclonic (PubMed ID:29106691)
17. Essential Hypertension (PubMed ID:33338514)
18. Fatty Liver (PubMed ID:30382123)
19. Fatty Liver, Alcoholic (PubMed ID:28935932)
20. Glioblastoma (PubMed ID:33864076)
21. Glucose Intolerance (PubMed ID:30382123)
22. Hyperglycemia (PubMed ID:31499052)
23. Hypertension, Renal (PubMed ID:33338514)
24. Liver Diseases (PubMed ID:31499052)
25. Lung Injury (PubMed ID:30801928)
26. Memory Disorders (PubMed ID:16406104)
27. Muscle Weakness (PubMed ID:30074247)
28. Muscular Dystrophy, Duchenne (PubMed ID:30074247)
29. Nausea (PubMed ID:21827451)
30. Neoplasm Metastasis (PubMed ID:22198381)
31. Oral Ulcer (PubMed ID:34269108)
32. Pain (PubMed ID:32345916)
33. Plaque, Amyloid (PubMed ID:33096116)
34. Psychoses, Substance-Induced (PubMed ID:16612464)
35. Recurrence (PubMed ID:28194850)
36. Schizophrenia (PubMed ID:16612464)
37. Spinal Cord Injuries (PubMed ID:28479140)
38. Stress Disorders, Post-Traumatic (PubMed ID:34262461)
39. Substance Withdrawal Syndrome (PubMed ID:29624642)
40. Tardive Dyskinesia (PubMed ID:30217539)
41. Tourette Syndrome (PubMed ID:30058466)
42. Urinary Bladder Neoplasms (PubMed ID:34575494)
43. Vomiting (PubMed ID:21827451)
44. Weight Gain (PubMed ID:30382123)

User Comments:

Subtotal: $0.00 HKD